POLYPEPTIDE FROM SEA ANEMONE HETERACtis crispa, HAVING ANALGESIC ACTION

摘要

FIELD: chemistry.SUBSTANCE: invention relates to biochemistry and specifically to biologically active polypeptides having analgesic action. Disclosed is a polypeptide ?-AnmTX Her 1b-1, having analgesic action and having the following amino acid sequence: HN-Gly-Thr-Pro-Cys-Lys-Ces-His7-Gly-Tyr-He-Gly-Val-Tyr-Trp-Phe-Met-Leu-Ala-Gly-Cys-Phe-Asn-Gly-lyr-Gly-lyr-Asn-Leu-Ser-Cys-Phc-lyr-Phe-Leu-Gly-He-Cys-Cys-Val-Asp-Arg-COOH.EFFECT: invention can be used in medicine to treat channelopathies associated with tissue acidosis and for identification of topology and molecular mechanisms of the functioning of the ASIC3 channel.4 dwg, 4 ex