| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to (R)-4-(heteroaryl)phenyl compounds of formula,where X represents heteroatom, selected from -S or O, Y represents H or residue, selected from group, consisting of - linear or branched C-C-alkyl, halogen-C-C-alkyl; Z represents heteroaryl ring, selected from group, consisting of unsubstituted tetrazole and triazole, pyrazole, thiazole, isoxazole, isothiazole, thiadiazole and oxadiazole, substituted with one hydroxyl group and optionally additionally substituted with linear C-C-alkyl. (R)-4-(heteroaryl)phenylethyl derivatives of formula (I), which can be used for application in treatment of diseases, into which C5a-induced human PMN-chemotaxis is involved. Formula (I) compounds, where Z represents tertazole, is obtained by interaction of formulacompound with trimethylsililazide.EFFECT: obtaining (R)-4-(heteroaryl)phenylethyl derivatives, possessing high selectivity and activity in inhibition of C5a-induced chemotaxis of neutrophils.7 cl, 1 tbl, 3 ex |
