PHARMACEUTICAL COMPOSITION AND CARDIAC HYPERTROPHY THERAPEUTIC DRUG CONTAINING FOR PREVENTING HYPERTROPHY

摘要

PURPOSE: A composition containing an expression or activation inhibitor of casein phosphorylase 2(CK2) protein is provided to treat or prevent cardiomegaly or cardiac insufficiency. CONSTITUTION: A composition for suppressing cardiomegaly contains an expression or activation inhibitor of CK2 protein as an active ingredient. The inhibitor suppresses phosphorylation by being conjugated at a serine site of histone deacetylase(HDAC2) protein. The inhibitor is CK2α1 siRNA(short interfering RNA) or a gene which transcribes the same. The inhibitor is apigenin of chemical formula 1, TBB(4,5,6,7-tetrabromobenzotriazole) of chemical formula 2, or TBCA((E)-3-(2,3,4,5-tetrabromophenyl) acrylic acid) of chemical formula 3.