| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to organic chemistry and specifically to novel spiro-linked 3H-pyrroles - 8-amino-1-imino-6-morpholin-4-yl-2-oxa-7-azaspiro[4.4]nona-3,6,8-triene-9-carbonitriles of general formula (1), where R=R=CH(1a); R+R=(CH)(1b); R+R=(CH)(1c); R+R=(CH)(1d). The method involves suspension of the corresponding 4-oxoalkane-1,1,2,2-tetracarbonitrile of formula (2) ,, R=R=CH(2a); R+R=(CH)(2b); R+R=(CH)(2c); R+R=(CH)(2d) in a mixture of water and propanol-2 in ratio of 10:1, followed by addition of morpholine in molar ratio of 1:2.EFFECT: high efficiency of the method.2 tbl |
