发明名称 |
Antibody induced cell membrane wounding |
摘要 |
Compositions and methods for inducing cell membrane wounding, cell permeabilization and cell killing are provided. The composition comprises a polyvalent agent that binds to a highly expressed cell surface antigen present on the surface of a cell. Preferably, the cell surface antigen is associated with the cytoskeleton of the cell. A preferred polyvalent agent is an IgM, and enhanced cell wounding and killing can be provided by the addition of a crosslinking agent. At sublethal concentrations in vivo, the cell wounding antibodies permeabilize cells and dramatically enhance response to chemotherapeutic agents, even in patients refractory to the chemotherapeutic agents.
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申请公布号 |
US8377435(B2) |
申请公布日期 |
2013.02.19 |
申请号 |
US20050267935 |
申请日期 |
2005.11.04 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY;BHAT NEELIMA M.;BIEBER MARCIA M.;TENG NELSON N. H.;SANDERS MARTIN E. |
发明人 |
BHAT NEELIMA M.;BIEBER MARCIA M.;TENG NELSON N. H.;SANDERS MARTIN E. |
分类号 |
A61K39/395;A61K39/00;C07K16/00;C12P21/08 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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