发明名称 |
Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof |
摘要 |
Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.
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申请公布号 |
US8378137(B2) |
申请公布日期 |
2013.02.19 |
申请号 |
US201113208176 |
申请日期 |
2011.08.11 |
申请人 |
XENOPORT, INC.;GALLOP MARK A.;DAI XUEDONG;SCHEUERMAN RANDALL A.;RAILLARD STEPHEN P.;MANTHATI SURESH K.;YAO FENMEI;PHAN THU;LUDWIKOW MARIA;PENG GE;BHAT SEEMA |
发明人 |
GALLOP MARK A.;DAI XUEDONG;SCHEUERMAN RANDALL A.;RAILLARD STEPHEN P.;MANTHATI SURESH K.;YAO FENMEI;PHAN THU;LUDWIKOW MARIA;PENG GE;BHAT SEEMA |
分类号 |
C07C271/22;C07C269/00;C07D207/404;C07D207/416;C07D207/46 |
主分类号 |
C07C271/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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