| 发明名称 |
METALLO-&bgr;-LACTAMASE INHIBITOR |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of a β-lactam antibiotic and recovering the antibacterial activity. <P>SOLUTION: A maleic acid derivative having a structure of general formula (I) has an inhibitory activity against the metallo-β-lactamase. The antibacterial activity of the β-lactam antibiotic against metallo-β-lactamase-producing bacteria can be recovered by combining the compound of general formula (I) with the β-lactam antibiotic. <P>COPYRIGHT: (C)2013,JPO&INPIT |
| 申请公布号 |
JP2013032361(A) |
申请公布日期 |
2013.02.14 |
| 申请号 |
JP20120203316 |
申请日期 |
2012.09.14 |
| 申请人 |
MEIJI SEIKA PHARMA CO LTD |
发明人 |
KONNAI TAKESHI;IDA MIZUYO;ABE TAKAO;HIRAIWA YUKIKO;MORINAKA AKIHIRO;KUDO TOSHIAKI |
| 分类号 |
A61K31/194;A61K31/225;A61K31/341;A61K31/351;A61K31/40;A61K31/4164;A61K31/4406;A61K31/443;A61K31/445;A61K31/4453;A61K31/495;A61K31/5375;A61K31/695;A61P31/04;A61P43/00;C07C57/13;C07C57/26;C07C57/34;C07C59/46;C07C59/52;C07C59/64;C07C59/68;C07C69/593;C07C69/618;C07C69/712;C07C69/716;C07C217/22;C07C233/65;C07C235/06;C07C237/52;C07C279/08;C07C323/54;C07D207/12;C07D211/14;C07D211/46;C07D213/55;C07D233/60;C07D295/16;C07D307/60;C07D307/62;C07D307/64;C07D309/06;C07D405/06;C07D407/04;C07F7/18 |
主分类号 |
A61K31/194 |
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