发明名称 |
NANOFLUIDIC BIOCHEMICAL SENSORS BASED ON SURFACE CHARGE MODULATED ION CURRENT |
摘要 |
<p>Biological and chemical sensors based on surface charge changes in a pore or channel, such as a nanopore or nanochannel, are employed to detect targeted analytes in an electrolyte solution having a low ion concentration. Receptors within the pore or channel capture a targeted analyte, causing a change in surface charge that affects ionic conductance. The change in ionic conductance is detected, evidencing the presence of the targeted analyte. A secondary tag may be introduced to the pore or channel for binding with a captured analyte in certain circumstances for causing a change in the surface charge.</p> |
申请公布号 |
WO2013022903(A1) |
申请公布日期 |
2013.02.14 |
申请号 |
WO2012US49878 |
申请日期 |
2012.08.07 |
申请人 |
INTERNATIONAL BUSINESS MACHINES CORPORATION;AFZALI-ARDAKANI, ALI;WAGGONER, PHILIP, S. |
发明人 |
AFZALI-ARDAKANI, ALI;WAGGONER, PHILIP, S. |
分类号 |
G01N27/26 |
主分类号 |
G01N27/26 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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