COMPOSITIONS AND USES

摘要

Compositions and methods comprising or using a combination of an amyloid beta mimotope and an adjuvant such as AS01B are provided. The compositions and methods provided are particularly useful for prevention or treatment of Alzheimer's disease. Suitable ß-amyloid mimotope sequences include DKELRI, SWEFRT, GAEFRFT, DWEFRD, SLEFRF, GREFRN, SEFKHG, ILFRHG, TLHEFRH, IRWDTP and HQKMIFA. The mimotope sequence may be conjugated to a protein carrier, optionally via an additional cysteine residue at the C terminus. Suitable adjuvants may comprise QS21, 3D-MPL or an AGP, optionally in combination with liposomes or oil in water emulsion.