发明名称 |
METHOD FOR GENERATING HYPERMUTABLE ORGANISM |
摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method for rendering cells hypermutable, and hypermutable cell lines altered genetically and phenotypically. <P>SOLUTION: The invention relates to use of dominant negative alleles of human mismatch repair genes to generate hypermutable cells and organisms; the use of introducing genes into cells and transgenic animals by which new cell lines and animal varieties with new and useful properties can be prepared more efficiently than by relying on the natural rate of mutation; and use of mutagens for enhancing a rate of further augmented mutation. <P>COPYRIGHT: (C)2013,JPO&INPIT |
申请公布号 |
JP2013031445(A) |
申请公布日期 |
2013.02.14 |
申请号 |
JP20120193802 |
申请日期 |
2012.09.04 |
申请人 |
JOHNS HOPKINS UNIV;MORPHOTEK INC;NICOLAIDES NICHOLAS C;SASS PHILIP M;GRASSO LUIGI;VOGELSTEIN BERT;KINZLER KENNETH W |
发明人 |
NICOLAIDES NICHOLAS C;SASS PHILIP M;GRASSO LUIGI;VOGELSTEIN BERT;KINZLER KENNETH W |
分类号 |
A01K67/027;C12N15/09;C07K14/47;C12N5/071;C12N15/01;C12N15/10;C12Q1/02;C12Q1/68;G01N33/15;G01N33/50;G01N33/53;G01N33/566 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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