FUSION POLYPEPTIDE CAPABLE OF ACTIVATING RECEPTOR

摘要

PROBLEM TO BE SOLVED: To provide multimeric fusion polypeptides capable of activating a target receptor requiring multimerization to be activated.

SOLUTION: A fusion polypeptide comprising (A)x-M-(A')y, wherein A and A' are each a polypeptide capable of binding a target receptor. The fusion polypeptides form multimeric proteins which activate the target receptor. A and A' can be each an antibody or fragment derived from an antibody specific for a target receptor, such as the same or different scFv fragments, and/or a ligand or ligand fragment or derivative capable of binding the target protein. M is a multimerizing component, and x and y are independently a number between 1-10.

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