发明名称 |
Homogenous Vaccine Composition Comprising a Conjugate of EGF and P64K for the Treatment of Tumors |
摘要 |
A vaccine composition for therapeutic use thereof on cancer patients includes a chemical conjugate of human recombining Epidermic Growth Factor (hrEGF) and a combining protein P64k for performing a conjugation reaction which produces said chemical conjugate in a controlled and reproducible manner. The preferred conjugate surprisingly increases the immunogenic activity causing significant increases in the anti-EGF antibody titers in humans, and provides a vaccine preparation with more than one type of effective dose presentation which enables the immunization dose per patient to be increased, but without involving an increase in immunization frequency and/or the number of immunization sites.
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申请公布号 |
US2013039940(A1) |
申请公布日期 |
2013.02.14 |
申请号 |
US201213346831 |
申请日期 |
2012.01.10 |
申请人 |
MARTINEZ GRYSSELL RODRIGUEZ;VINA RODRIGUEZ LISEL;CALVO GONZALEZ LOANY;CUEVAS FIALLO ARIADNA;CHICO VELIZ ERNESTO;LAGE DAVILA AGUSTIN BIENVENIDO;RAMOS TANIA CROMBET;ALBISA NOVO ARAMA;GONZALEZ MARINELLO GISELA MARIA |
发明人 |
MARTINEZ GRYSSELL RODRIGUEZ;VINA RODRIGUEZ LISEL;CALVO GONZALEZ LOANY;CUEVAS FIALLO ARIADNA;CHICO VELIZ ERNESTO;LAGE DAVILA AGUSTIN BIENVENIDO;RAMOS TANIA CROMBET;ALBISA NOVO ARAMA;GONZALEZ MARINELLO GISELA MARIA |
分类号 |
A61K39/385;A61P35/00;A61P37/04 |
主分类号 |
A61K39/385 |
代理机构 |
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地址 |
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