PBAP48 TRANSGENIC MICE FOR DRUG DISCOVERY IN AGE-RELATED MEMORY DECLINE
摘要
Described is a transgenic mouse with two transgenes, each of which transgene comprises a DNA sequence encoding a dominant negative form of RbAp48 protein, wherein the expression of the dominant negative form of RbAp48 is spatially restricted to the forebrain by a CaM Kinase Ila promoter and wherein the expression of the dominant negative form of RbAp48 is controlled by tetracycline-controlled transcriptional activation. Also provided are methods for evaluating in the transgenic mouse the potential therapeutic effect of an agent for slowing, inhibiting or preventing age-related memory decline in a mammalian subject.
申请公布号
WO2013022715(A2)
申请公布日期
2013.02.14
申请号
WO2012US49385
申请日期
2012.08.02
申请人
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK;SMALL, SCOTT, A.;PAVLOPOULOS, ILIAS;KANDEL, ERIC, R.
发明人
SMALL, SCOTT, A.;PAVLOPOULOS, ILIAS;KANDEL, ERIC, R.