| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide an improved method for restoring a biological structure of an intervertebral disc and improving a function thereof. <P>SOLUTION: Methods and compositions for the biological repair of cartilage using a hybrid construct combining both an inert structure and living core are described. The inert structure is intended to act not only as a delivery system to feed and grow a living core component, but also as an inducer of cell differentiation. The inert structure comprises concentric internal and external and inflatable/expandable balloon-like bio-polymers. The living core comprises the cell-matrix construct comprised of HDFs, for example, seeded in a scaffold. The method comprises surgically removing a damaged cartilage from a patient and inserting the hybrid construct into the cavity generated after the surgical intervention. The balloons of the inert structure are successively inflated within the target area, such as a joint, for example. <P>COPYRIGHT: (C)2013,JPO&INPIT |
