SYNTHESIS OF 18F-LABELED TRACERS IN HYDROUS ORGANIC SOLVENTS
摘要
A method for synthesizing an 18F-labeled probe. The method includes a step of eluting an amount of 18F with a first solvent which includes a predetermined amount of water and at least one organic solvent. In this step, the 18F elutes as an 18F solution. The method also includes a step of using the 18F solution to perform 18F-labeling in the presence of at least one labeling reagent and at least one phase transfer catalyst so as to generate the 18F-labeled probe. In the method, there is no step of drying the 18F starting from a time when the eluting step is performed and ending at a time when the 18F-labeling step is performed.
申请公布号
EP2556372(A1)
申请公布日期
2013.02.13
申请号
EP20110715812
申请日期
2011.04.08
申请人
SIEMENS MEDICAL SOLUTIONS USA, INC.
发明人
GANGADHARMATH, UMESH, B.;KOLB, HARTMUTH, C.;WALSH, JOSEPH, C.