| 摘要 |
<p>Substituted triazene compounds (I) are new. Substituted triazene compounds of formula (I) or their salts are new. R1, R2 : alkyl, alkenyl or aryl (all optionally substituted); X1 : a single bond, carbonyl, S, O, sulfoxy, sulfonyl, azo or an optionally substituted, optionally saturated 1-6C-aliphatic group; R11 : (a) OH, (b) a group comprising acyl, acyloxy, sulfonyl (-SO 2R), sulfonyloxy (-O-SO 2R), alkyl, alkoxy, aryloxy, alkenyl, alkynyl or aryl (all optionally substituted), halo, CN, nitro, carboxyl, alkoxycarbonyl, aminocarbonyl, sulfonic acid or sulfate or (c) a group comprising aryloxy, acyloxy, sulfonyloxy, alkoxy (all optionally substituted) or sulfate, where aminocarbonyl substituted alkoxy of formula (NR 2-C(=O)-(CH 2) n-O-) is excluded; n : 1-7; and R3-R10 : H or OH, where optionally at least one of R7-R10 and optionally at least one of R3-R6 is OH and the other R3-R10 are not H and the remaining R11 is the group (b), at lease one of R7-R11 is CH 3O and the other R7-R11 are not CH 3and R3-R6 are H, R11 is group (c) and R3-R10 are H, at least one of R7-R11 and optionally at least one of R3-R6 are optionally substituted alkoxy from a sugar bonded via O and the other R3-R11 are acyl, acyloxy, sulfonyl (-SO 2R), sulfonyloxy (-O-SO 2R), alkyl, alkoxy, aryloxy, alkenyl, alkynyl, aryl (all optionally substituted), H, OH, halo, CN, nitro, carboxy, alkoxycarbonyl, aminocarbonyl, sulfonic acid or sulfate. N.B. R is not defined. Independent claims are included for: (1) the preparation of (I); (2) a composition comprising (I) and one or more carriers, excipients and/or solvents; and (3) a combination preparation comprising (I) and at least one further active compound. [Image] ACTIVITY : Cytostatic. MECHANISM OF ACTION : None given.</p> |
