| 摘要 |
PURPOSE: An anti-restenosis agent containing 4-O-methylhonokiol is provided to safely prevent and treat coronary arthery diseases. CONSTITUTION: An anti-restenosis agent contains 4-O-methylhonokiol of general formula 1 as an active ingredient and pharmaceutically acceptable carrier. A method for preparing 4-O-methylhonokiol comprises: a step of obtaining crude extract from leaves or stem barks of Magnolia officinalis Rehd. et Wils.; a step of isolating the crude extract with non-polar solvent to obtain a soluble extract; a step of dissolving the non-polar solvent solution extract; and a step of performing column chromatography using C18 column, silicagel column, and Shim-pak prep-ODS colum. |
