发明名称 |
High-concentration protein formulations and method of manufacture |
摘要 |
Provided is a pharmaceutical composition involving a concentrated mixture of a precipitated protein and a liquid medium and a method for manufacturing the concentrated mixture. The concentrated mixture is manufacturable by precipitation of a protein with a biocompatible polymer precipitating agent, followed by removal of sufficient liquid to concentrate the resulting mixture to the desired degree. The precipitated protein can be stored for a significant time in the concentrated mixture, such as intermediate between processing stages during manufacture operations.
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申请公布号 |
US8372798(B2) |
申请公布日期 |
2013.02.12 |
申请号 |
US20020271832 |
申请日期 |
2002.10.16 |
申请人 |
ENDO PHARMACEUTICALS COLORADO, INC.;CARPENTER JOHN F.;ETTER JEFFREY B.;SAMANIEGO ADRIAN C. |
发明人 |
CARPENTER JOHN F.;ETTER JEFFREY B.;SAMANIEGO ADRIAN C. |
分类号 |
A61K9/10;A61K49/14;A61K9/00;A61K9/14;A61K38/00;A61K39/395;A61K47/10;A61K47/22;A61K47/26;A61K47/34;A61P19/02;A61P29/00;A61P35/00;C07K1/02 |
主分类号 |
A61K9/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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