发明名称 |
Rare cell analysis using sample splitting and DNA tags |
摘要 |
The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with different labels wherein each label is specific to each cell and quantifying the labeled regions of genomic DNA from each cell in the mixed sample. More particularly the invention involves quantifying labeled DNA polymorphisms from each cell in the mixed sample.
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申请公布号 |
US8372584(B2) |
申请公布日期 |
2013.02.12 |
申请号 |
US20070763421 |
申请日期 |
2007.06.14 |
申请人 |
THE GENERAL HOSPITAL CORPORATION;GPB SCIENTIFIC, LLC;VERINATA HEALTH, INC.;SHOEMAKER DANIEL;TONER MEHMET;KAPUR RAVI;STOUGHTON ROLAND |
发明人 |
SHOEMAKER DANIEL;TONER MEHMET;KAPUR RAVI;STOUGHTON ROLAND |
分类号 |
C12Q1/68;G01N33/48 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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