| 摘要 |
Biologically active polypeptides containing the following polypeptide segment: -ALA-LYS-SER-GLN- are disclosed. Biological activity is generally retained upon substitution of an amino acid radical selected from L- asparagyl, L-glutamyl, L-threonyl, glycyl, L-valyl, L-leucyl, L-alamyl, L- seryl, sarcosyl, 2-methylalonyl, D- asparagyl, D-glutamyl, D-threonyl, D- valyl, D-leucyl, D-alamyl and D-seryl for either or both of L-alanyl in the first position and L-seryl in the third position, which polypeptides are capable of induction of the differentiation of T-lymphocytes, as measured by the acquisition of the thymic differentiation antigen Th-1, as well as B-lymphocytes as measured by the acquisition of the differentiation antigen Bu-1. The polypeptides are thus useful in thymic function and immunity areas such as in treatment for congential absence of thymus. Also provided are methods of manufacture of the polypeptides, therapeutic compositions, and methods of use of the polypeptides. |
