| 发明名称 |
Wnt Antagonists and Methods of Treatment and Screening |
| 摘要 |
The present invention relates to compositions comprising Wnt antagonists and methods of treating Wnt-associated diseases and disorders, such as cancer, inducing differentiation, and reducing the frequency of cancer stem cells, as well as novel methods of screening for such Wnt antagonists. In particular, the invention discloses soluble FZD, SFRP and Ror receptors and their use.
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| 申请公布号 |
US2013034551(A2) |
申请公布日期 |
2013.02.07 |
| 申请号 |
US201113005214 |
申请日期 |
2011.01.12 |
| 申请人 |
ONCOMED PHARMACEUTICALS, INC.;SATYAL SANJEEV;MITRA SATYAJIT;GURNEY AUSTIN |
发明人 |
SATYAL SANJEEV;MITRA SATYAJIT;GURNEY AUSTIN |
| 分类号 |
A61K39/395;A61P35/00;C07H21/00;C07K14/47;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/09;C12N5/10;C12P21/02;G01N33/566 |
主分类号 |
A61K39/395 |
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