发明名称 |
Direct analysis of biomolecules from the blood spot on paper using matrix assisted laser desorption ionization-mass spectrometry |
摘要 |
PURPOSE: A method for directly analyzing a biocompound in blood from a blood sample stained on paper is provided to directly analyze the biocompound and to enable quick and reproducible analysis. CONSTITUTION: A method for directly analyzing a biocompound from a blood sample on a sheet of paper comprises: a step of staining the blood sample on the paper; a step of applying alpha-cyano-4-hydroxy cinnamic acid onto the paper and crystallizing in a thin film form; and a step of detecting the biocompound in the blood using laser desorption/ionization-mass spectrometry. The biocompound contains choline or heme B. The crystallization is performed by spraying alpha-cyano-4-hydroxy cinnamic acid onto the blood sample. The thickness of the paper is 150-500 um. |
申请公布号 |
KR101231157(B1) |
申请公布日期 |
2013.02.08 |
申请号 |
KR20110067573 |
申请日期 |
2011.07.07 |
申请人 |
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发明人 |
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分类号 |
G01N27/62;G01N30/72;G01N30/90;G01N33/49 |
主分类号 |
G01N27/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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