| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a novel manufacturing process, novel process steps, and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors. <P>SOLUTION: The process for manufacturing a compound of formula (III) (wherein R, R<SB POS="POST">1</SB>, R<SB POS="POST">2</SB>, and R<SB POS="POST">3</SB>are each hydrogen or the like and PG is an amino protecting group) or a salt thereof comprises transforming the hydroxyl group into a halogen or a sulfonate of an organic sulfonic acid and thereafter allowing the group thus transformed to react with the protected amino group to form a pyrrolidine ring of formula (III). <P>COPYRIGHT: (C)2013,JPO&INPIT |
