发明名称 |
METHODS AND COMPOSITIONS FOR MODULATING THE INNATE IMMUNE RESPONSE AND/OR MYOGENESIS IN A MAMMALIAN SUBJECT |
摘要 |
In one aspect, the present invention relates to methods for increasing, decreasing or maintaining the innate immune response in a mammalian subject comprising modulating the expression of DUX4-fl, or modulating the expression of beta-defensin 3 (DEFB103). In another aspect, the present invention relates to methods for increasing, decreasing or maintaining myogenesis or muscle differentiation in a mammalian subject comprising modulating the expression of beta-defensin 3 (DEFB103). In additional aspects, the present invention involves diagnostic methods based on assessement of identified biomarkers. |
申请公布号 |
CA2843636(A1) |
申请公布日期 |
2013.02.07 |
申请号 |
CA20122843636 |
申请日期 |
2012.07.27 |
申请人 |
FRED HUTCHINSON CANCER RESEARCH CENTER |
发明人 |
TAPSCOTT, STEPHEN J.;GENG, LINDA |
分类号 |
A61K39/395;A61K31/7088;A61K31/7105;A61K48/00;A61P37/00 |
主分类号 |
A61K39/395 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|