发明名称 |
1,4-DIARYL-2-AZETIDINONES WITH ANTI-TUMORAL ACTIVITY |
摘要 |
<p>Disclosed are compounds of formula (I): wherein one of A and B is the group:(II) wherein R1 is selected from H and OCH3, and the other is the group:(III) wherein R2 is selected from H, OH, NO2, NH2; R3 is selected from OH and NH2;15 the salts, enantiomers and diastereoisomers thereof; with the exclusion of the following compounds: 3,4-cis-3-hydroxy-4-(3-nitro-4-methoxyphenyl)-1-(3,4,5- trimethoxyphenyl)azetidin-2-one; 3,4-cis-4-(3-amino-4-methoxyphenyl)-3-hydroxy-1-(3,4,5-20 trimethoxyphenyl)-azetidin-2-one; for use as antitumor agents.</p> |
申请公布号 |
WO2013017548(A1) |
申请公布日期 |
2013.02.07 |
申请号 |
WO2012EP64825 |
申请日期 |
2012.07.27 |
申请人 |
UNIVERSITA' DEGLI STUDI DI MILANO;UNIVERSITA' DEGLI STUDI DI MILANO - BICOCCA;PAGLIARIN, ROBERTO;ORSINI, FULVIA;MONTANO, GIUSEPPE;TRIPODI, FARIDA;COCCETTI, PAOLA;FUSI, PAOLA ALESSANDRA |
发明人 |
PAGLIARIN, ROBERTO;ORSINI, FULVIA;MONTANO, GIUSEPPE;TRIPODI, FARIDA;COCCETTI, PAOLA;FUSI, PAOLA ALESSANDRA |
分类号 |
C07D205/08;A61K31/397;A61P35/00;C07D205/085 |
主分类号 |
C07D205/08 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|