MICRORNA MODULATORS AND METHOD FOR IDENTIFYING AND USING THE SAME
摘要
<p>The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.</p>
申请公布号
WO2013019469(A1)
申请公布日期
2013.02.07
申请号
WO2012US47920
申请日期
2012.07.24
申请人
THE WISTAR INSTITUTE;NORTH CAROLINA STATE UNIVERSITY;HUANG, QIHONG;DEITERS, ALEXANDER;GUMIREDDY, KIRANMAI