NOVEL GRANULE FORMULATION CONTAINING SILDENAFIL OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS AN ACTIVE INGREDIENT

摘要

Disclosed is a rapidly dissolving granule formulation that is rapidly dissolved in the oral cavity. The granule formulation is rapidly dissolved in the oral cavity within 20 seconds after oral administration without leaving a feeling of foreign matter and a residual feeling. The granule formulation is produced by mixing an active ingredient with a rapidly dissolving carrier and granulating the mixture. The rapidly dissolving carrier meets the requirements: an instantaneous solubility of at least 30 mg/ml; a solubility after 5 minutes of at least 50 mg/ml; and the instantaneous solubility being 90% or less of a maximum solubility. The granule formulation can accomplish the desired effects irrespective of the kind of active ingredient. Therefore, the granule formulation is applicable to various active ingredients. In addition, the granule formulation can be produced in a relatively simple manner. This allows for an economical and efficient production process.