发明名称 |
DOUBLE-STRANDED OLIGONUCLEOTIDE COMPOUNDS FOR TREATING HEARING AND BALANCE DISORDERS |
摘要 |
The present application relates to double stranded nucleic acid compounds, compositions comprising same and methods of use thereof for the treatment of hearing loss in a subject in need thereof. The compounds are preferably chemically synthesized and modified dsRNA molecules which inhibit expression of a gene expressed selected from the group consisting of HES1, HES5, HEY1, HEY2, ID1, ID2, ID3, CDKN1B, and NOTCHl. |
申请公布号 |
CA2842954(A1) |
申请公布日期 |
2013.02.07 |
申请号 |
CA20122842954 |
申请日期 |
2012.08.03 |
申请人 |
QUARK PHARMACEUTICALS, INC. |
发明人 |
FEINSTEIN, ELENA;AVKIN-NACHUM, SHARON;METT, IGOR;KALINSKI, HAGAR |
分类号 |
C12N15/113;A61K31/7088;A61K31/713;A61P27/16;C07H21/00;C12N5/10 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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