| 发明名称 |
Interleukin-12 P40 Variants with Improved Stability |
| 摘要 |
Modified interleukin-12 (IL-12) p40 polypeptides are disclosed. The modified polypeptides have alterations in the IL-12p40 subunit to eliminate the protease site between positions Lys260 and Arg261. The modified IL-12p40 polypeptides according to the invention have improved stability compared to wild-type mature human IL-12p40 polypeptides.
|
| 申请公布号 |
US2013034518(A1) |
申请公布日期 |
2013.02.07 |
| 申请号 |
US201213478897 |
申请日期 |
2012.05.23 |
| 申请人 |
MERCK PATENT GMBH;WEBSTER GORDON D.;MCKENZIE SUZANNE P.;LO KIN-MING;STEIN PASCAL ANDRE |
发明人 |
WEBSTER GORDON D.;MCKENZIE SUZANNE P.;LO KIN-MING;STEIN PASCAL ANDRE |
| 分类号 |
A61K38/20;A61P35/00;A61P37/06 |
主分类号 |
A61K38/20 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
