发明名称 |
AMIDE DERIVATIVES BEARING A CYCLOPROPYLAMINOACARBONYL SUBSTITUENT USEFUL AS CYTOKINE INHIBITORS |
摘要 |
The invention concerns a compound of the Formula (I), wherein Qa is heteroaryl and is substituted with halogeno; R1 and R2 are hydrogen; and Qb is phenyl or heteroaryl, and Qb may optionally bear 1 or 2 substituents selected from hydroxy, halogeno and (1-6C)alkyl, or a pharmaceutically-acceptable salt thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.
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申请公布号 |
US2013035346(A1) |
申请公布日期 |
2013.02.07 |
申请号 |
US201213628958 |
申请日期 |
2012.09.27 |
申请人 |
ASTRAZENECA AB;ASTRAZENECA AB |
发明人 |
BROWN DEARG SUTHERLAND;CUMMING JOHN GRAHAM;NASH IAN ALUN |
分类号 |
A61K31/505;A61K31/16;A61K31/42;A61K31/426;A61K31/433;A61K31/437;A61K31/44;A61K31/506;A61P1/00;A61P9/00;A61P11/00;A61P11/06;A61P17/06;A61P19/02;A61P25/00;A61P29/00;A61P31/14;C07C237/28;C07D211/70;C07D213/30;C07D239/34;C07D261/06;C07D277/04;C07D277/24;C07D285/06;C07D285/10;C07D403/02;C07D417/02;C07D471/04 |
主分类号 |
A61K31/505 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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