发明名称 |
COMPOSITIONS AND METHODS FOR MODULATION OF LMNA EXPRESSION |
摘要 |
Disclosed herein are compounds, compositions and methods for modulating the expression of LMNA in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Further provided are methods of identifying cis splicing regulatory elements of a selected mRNA using the disclosed compounds.
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申请公布号 |
US2013035370(A1) |
申请公布日期 |
2013.02.07 |
申请号 |
US201213566922 |
申请日期 |
2012.08.03 |
申请人 |
ISIS PHARMACEUTICALS, INC.;BENNETT C. FRANK;DOBIE KENNETH W.;FREIER SUSAN M.;CROOKE STANLEY T. |
发明人 |
BENNETT C. FRANK;DOBIE KENNETH W.;FREIER SUSAN M.;CROOKE STANLEY T. |
分类号 |
A61K31/712;C12N5/071 |
主分类号 |
A61K31/712 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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