发明名称 |
PHARMACEUTICAL COMPOSITION FOR TREATMENT OF THROMBOSIS-RELATED DISEASES COMPRISING A FRAGMENT OF PROLACTIN (PRL)-GROWTH HORMONE (GH)-PLACENTAL LACTOGEN (PL)-FAMILY PROTEIN |
摘要 |
The present disclosure relates to a pharmaceutical composition for use in the preventive and/or therapeutic treatment of thrombosis-related diseases or conditions relating to high level of plasminogen activator inhibitor 1 (PAI-1) expression, which composition comprises: A) a fragment of a polypeptide or protein of prolactin (PRL)-growth hormone (GH)-placental lactogen (PL)-family and homologous derivatives thereof, which fragment comprises from 6 to 14 consecutive amino acid residues of the amino acid sequence having general formula (I); or B) a peptide or a recombinant protein comprising said peptide, wherein the peptide is from 6 to 50 amino acids in length and has the activity to inhibit PAI-1, said peptide comprising from 6 to 14 consecutive amino acid residues of the amino acid sequence of general formula (I); or C) a polynucleotide encoding said fragment of a polypeptide or protein of A) or said peptide or recombinant protein of B).
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申请公布号 |
US2013035289(A1) |
申请公布日期 |
2013.02.07 |
申请号 |
US201113579556 |
申请日期 |
2011.02.16 |
申请人 |
UNIVERSITE DE LIEGE;STRUMAN INGRID;MARTIAL JOSEPH;BAJOU KHALID;D'AMICO SALVINO |
发明人 |
STRUMAN INGRID;MARTIAL JOSEPH;BAJOU KHALID;D'AMICO SALVINO |
分类号 |
A61K38/10;A61K38/08;A61K38/36;A61P7/02;A61P9/10 |
主分类号 |
A61K38/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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