发明名称 |
HYDRAZIDE CONTAINING NUCLEAR TRANSPORT MODULATORS AND USES THEREOF |
摘要 |
The invention generally relates to nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to a compound represented by structural formula (I): or a pharmaceutically acceptable salt thereof, wherein the values and alternative values for the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity. |
申请公布号 |
CA2842362(A1) |
申请公布日期 |
2013.02.07 |
申请号 |
CA20122842362 |
申请日期 |
2012.07.26 |
申请人 |
KARYOPHARM THERAPEUTICS, INC. |
发明人 |
SANDANAYAKA, VINCENT P.;SHACHAM, SHARON;MCCAULEY, DILARA;SHECHTER, SHARON |
分类号 |
C07D249/08;A61K31/4439;A61K31/497;A61K31/498;A61K31/506;A61K31/5377;A61K31/55;A61P27/02;A61P29/00;A61P31/12;A61P35/00;C07D401/12;C07D403/12;C07D409/12 |
主分类号 |
C07D249/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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