| 摘要 |
Rifamycin S was prepd. biologically by hydrolysis of rifamycin B aq. soln. by rifamycin oxidative hydrolase, which was separated from culture soln. of Hanicola spp.R-21 (KFCC 10024), Monocillium spp. R-11 (KFCC 10025) or Curvularia tetramea (KFCC 10026). By this method, recovery of organic solvent and addition of oxidase are unnecessary, final product is purified without difficulty and formation of by-product is minimized because the reaction proceeds at neutral pH.
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