Methods for prediction of clinical outcome to epidermal growth factor receptor inhibitors by cancer patients
摘要
The present invention relates to a method to obtain an expression score to evaluate gene expression in a tissue specimen obtained from a person having or suspected of having cancer comprising:
a) determining by immunohistochemistry a fraction score, wherein the fraction score corresponds to the percentage of cells in the tissue specimen that stain positive for a biomarker;
b) determining an intensity score that corresponds to the staining intensity of the biomarker in the sample of tumor cells;
c) calculating an expression score that is a numerical evaluation of the product of the fraction score and the intensity score.
申请公布号
EP2527460(A9)
申请公布日期
2013.02.06
申请号
EP20120005855
申请日期
2005.05.26
申请人
THE REGENTS OF THE UNIVERSITY OF COLORADO
发明人
GARCIA, MARILEILA VARELLA;BUNN, PAUL A., JR.;CAPPUZZO, FEDERICO;FRANKLIN, WILBUR A.;HIRSCH, FRED R.