发明名称 |
Mutations in the epidermal growth factor receptor gene |
摘要 |
The invention relates to a new identified mutation in the epidermal growth factor receptor gene, leading to an amino acidic change which highly correlates with the resistance to a therapy regimen comprising cetuximab and the sensitivity to a therapy regimen comprising panitumumab. The invention includes peptide sequences, primers and probes to detect such a mutation, as well as kits for predicting the response of a subject to a therapy regime comprising cetuximab and/or panitumumab. In particular, the invention is useful in the therapy regimen applicable to metastasic colorectal cancer and to head and neck cancer. |
申请公布号 |
EP2554551(A1) |
申请公布日期 |
2013.02.06 |
申请号 |
EP20110382270 |
申请日期 |
2011.08.03 |
申请人 |
FUNDACIO INSTITUT MAR D'INVESTIGACIONS MEDIQUES (IMIM) |
发明人 |
MONTAGUT VILADOT, CLARA;ALBANELL MESTRES, JOAN;ROVIRA GUERIN, ANA;BELLOSILLO PARICIO, BEATRIZ;DALMASES MASSEGU, ALBA |
分类号 |
C07K14/71;C12Q1/68;G01N33/574 |
主分类号 |
C07K14/71 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|