摘要 |
<p>PURPOSE: A mixed mode ligand is provided to connect a solid support to a ligand with a covalent bond and to comprise a linker with at least one C, O, N, or S atom by providing a substrate with the solid supporter, the ligand, and the linker. CONSTITUTION: A mixed mode ligand comprises a solid supporter, a ligand, and a linker. The ligand is indicated with a chemical formula, the linker comprises at least one of a C, O, N, or S atom. The linker connects the solid supporter to the ligand by a covalent bond by locating at the wave line indication on the upper part of the ligand. [Reference numerals] (AA) Ligand DBC for ligand density vs. IgG; (BB) Ligand density(umol); (CC) Ligand DBC(mg/ml); (DD) Ligand density and DBC; (EE) Resin</p> |