发明名称 PYRIPYROPENE DERIVATIVES HAVING ACAT2 INHIBITING ACTIVITY AND STABLE TO METABOLIZING ENZYMES
摘要 A compound effective in prevention and treatment of arteriosclerosis with a mechanism different from that of statin drugs has the following formula or a pharmaceutically acceptable salt, solvate, or hydrate thereof: wherein R 1 is an aliphatic, alicyclic, or aromatic acyloxy group, or a group of the formula -O-CH(R 7 )-R 8 where R 7 is a lower alkoxy group and R 8 is an aryl group, and R 2 is carboxyl, a lower alkoxycarbonyl group, or an arylmethylcarbamoyl group, or a -CH 2 -acyloxy group and R 3 is an aliphatic, alicyclic or aromatic acyloxy group, provided that at least one of R 4 and R 3 is a group other than acetoxy, or R 2 and R 3 taken together form a group of the formula -O-CH(R 5 )-O- where R 5 is an aryl group.
申请公布号 EP2554546(A1) 申请公布日期 2013.02.06
申请号 EP20110762699 申请日期 2011.03.25
申请人 SCHOOL JURIDICAL PERSON KITASATO INSTITUTE 发明人 TOMODA HIROSHI;NAGAMITSU TOHRU;MATSUDA DAISUKE;OHSHIRO TAICHI;OHTAWA MASAKI;OMURA SATOSHI
分类号 C07D493/04;A61K31/453;A61P9/10;A61P43/00;C07D493/14 主分类号 C07D493/04
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