NEW COMPOUND, THE PREPARATION THEREOF AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME FOR ANTI-ANGIOGENIC DRUG

摘要

PURPOSE: A pharmaceutical composition containing a compound which suppresses angiogenesis is provided to prevent and treat diseases caused by angiogenesis suppression abnormality. CONSTITUTION: A compound which suppresses angiogenesis is denoted by chemical formula I. The compound of chemical formula I or pharmaceutically acceptable salts thereof is 2-(1-benzylpiperidine-4-ylamino)-N-(3-chlorphenyl)nicotiamide[103]or pharmaceutically acceptable salts thereof. A method or preparing the compound of chemical formula I comprises a step of reacting a compound of chemical formula II and a compound of chemical formula III under the presence of a base. The base is triethyl amine, N,N-diisopropylethyl amine, N-methylmorpholine, DBU(1,8-diazabicyclo[5.4.0]undec-7-ene), N-methylpiperidine, 4-dimethylaminopyridine, N,N-dimethylaniline, 2,6-lutidine, 4-N,N-dimethylaminopyridine, or pyridine. A pharmaceutical composition for preventing or treating diseases or symptoms caused by VEGF(Vascular Endothelial Growth Factor) abnormality contains the compound of chemical formula I or the salts.