发明名称 Pharmaceutical composition which improves in vivo gene transfer
摘要 A pharmaceutical composition, including at least one nucleic acid, a Tyrode's medium having 140 mM NaC1, 6 mM KC1, 3 mM CaC12, 2 mM MgC12, 10 mM Hepes, pH 7.4, and 10 mM glucose; and a tetrafunctional copolymer of formula (I): where x and y represent, independently of one another, an integer of between 1 and 500, the tetrafunctional copolymer is in a form of a mineral salt wherein said tetrafunctional copolymer is in a cationic form. The compound of formula (I) has a molecular weight of between 1,000 and 25,000 g/mol and an EO/PO ratio of 0.8 to 1.2.
申请公布号 US8367631(B2) 申请公布日期 2013.02.05
申请号 US20100659618 申请日期 2010.03.15
申请人 INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE;PITARD BRUNO 发明人 PITARD BRUNO
分类号 A61K47/04;A61K48/00;A01N63/00;A01N65/00;A61K31/7088;A61K31/77;A61K31/785;A61K38/16;A61K38/46;A61K47/34;A61P21/00;A61P43/00;C07H21/02;C07H21/04;C12N5/00;C12N5/02 主分类号 A61K47/04
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