| 发明名称 |
NON-INVASIVE DIAGNOSTIC IMAGING TECHNOLOGY FOR MITOCHONDRIA DYSFUNCTION USING RADIOLABELED LIPOPHILIC SALTS |
| 摘要 |
The invention provides a series of lipophilic phosphonium cations (PhCs) labeled with18F, having the following formula: (see above formula) wherein R1 to R4, p, q and r are as defined herein, for non-invasive assessment of .DELTA..PSI.m, lipophilic ammonium cation analogs of the PhCs, and methods of using same for imaging and detection of mitochondrial-related pathologies in patients using PET or SPECT. |
| 申请公布号 |
CA2474142(C) |
申请公布日期 |
2013.02.05 |
| 申请号 |
CA20032474142 |
申请日期 |
2003.02.06 |
| 申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
MADAR, IGAL;RAVERT, HAYDEN T.;DANNALS, ROBERT;SCHEFFEL, URSULA A.;FROST, JAMES J. |
| 分类号 |
A61K51/00;C07F9/54;A61B6/00;A61K49/00;A61K51/04;A61P35/00;C07B59/00;C07C211/63;C07C211/64;C07F9/58 |
主分类号 |
A61K51/00 |
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