发明名称 Aminopyridine derivatives having aurora a selective inhibitory action
摘要 The present invention relates to a compound of Formula (I): wherein: R1 is H, —NHCOOR1a, C5-6 cycloalkyl, or phenyl; where the cycloalkyl and phenyl each independently may be substituted with one to three of the same or different substituents selected from R10; R1a is C1-3 alkyl which may be substituted with one to three of the same or different substituents selected from F and Cl; R2 is H, —COOH, —CH2 COOH, —COOR2a, or —CH2COOR2a; R2a is C1-2 alkyl, where the alkyl may be substituted with one to three of the same or different substituents selected from halogen atoms; R3 is H, C1-6 alkyl, where the alkyl may be substituted with one to three of the same or different substituents selected from R11; R10 is F, Cl, CF3, or C1-2 alkyl; R11 is halogen atom, hydroxy, or cyano; W is selected from: W2a is H, halogen atom, cyano, C1-2 alkyl, or C3-5 cycloalkyl, or a pharmaceutically acceptable salt or ester thereof.
申请公布号 US8367690(B2) 申请公布日期 2013.02.05
申请号 US201013259620 申请日期 2010.03.15
申请人 VERTEX PHARMACEUTICALS INC.;MSD K.K.;BINCH HAYLEY;HASHIMOTO MASAYA;MORTIMORE MICHAEL;OHKUBO MITSURU;SUNAMI TOMOKO 发明人 BINCH HAYLEY;HASHIMOTO MASAYA;MORTIMORE MICHAEL;OHKUBO MITSURU;SUNAMI TOMOKO
分类号 A01N43/54;A61K31/505 主分类号 A01N43/54
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