发明名称 |
Extended release dosage forms of propranolol hydrochloride |
摘要 |
A unit dosage form, such as a capsule or the like for delivering drugs into the body in a sustained release fashion similar to that produced by INDERAL® LA indicated for the treatment of cardiovascular diseases, comprises two populations of propranolol-containing particles (beads, pellets, granules, etc.). Each bead population exhibits a pre-designed rapid release profile (i.e., substantially complete release within 60 minutes) or sustained release profile over a period of 24 hours. Such a cardiovascular drug delivery system is designed by combining immediate release (IR) beads and sustained release (SR) beads. SR beads may be obtained by membrane coating IR beads with a water-insoluble polymer such as ethylcellulose or a mixture of a water insoluble polymer and a water-soluble polymer such as hydroxypropylcellulose at a ratio of from about 65/35 to 95/5.
|
申请公布号 |
US8367111(B2) |
申请公布日期 |
2013.02.05 |
申请号 |
US20020335295 |
申请日期 |
2002.12.31 |
申请人 |
APTALIS PHARMATECH, INC.;VENKATESH GOPI M.;VISHNUPAD KRISHNA S.;PERCEL PHILLIP J. |
发明人 |
VENKATESH GOPI M.;VISHNUPAD KRISHNA S.;PERCEL PHILLIP J. |
分类号 |
A61K9/14;A61K9/26;A61K9/48;A61K9/50 |
主分类号 |
A61K9/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|