MATURATION METHOD FOR DENDRITIC CELL USING M.TUBERCULOSIS RV0577

摘要

PURPOSE: A composition which contains RV0577 and induces dendritic cell maturation is provided to effectively activate immune response. CONSTITUTION: A composition which induces dendritic cell matutaton contains 1-10 ug/ml of RV0577 protein as an active ingredient. The protein is derived from M-tuberculosis. RV0577 protein enhances the expression of CD(Cluster of Differentiation)80, CD86, MHC(Major Histocompatibility Complex)-class I, II in a dendritic cell. A method for inducing maturation of the immature dendritic cells comprises: a step of sorting the immature dendritic cells; and a step of treating 1-10 ug/ml of RV0577 protein to the sorted immature dendritic cells.