发明名称 PRODRUGS OF PIPERAZINE AND SUBSTITUTED PIPERIDINE ANTIVIRAL AGENTS
摘要 This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection. wherein: X is C or N with the proviso that when X is N, R1 does not exist; W is C or N with the proviso that when W is N, R2 does not exist; V is C; E is hydrogen or a pharmaceutically acceptable salt thereof; and Y is selected from the group consisting of Also, this invention provides for intermediate Compounds II useful in making prodrug Compounds I. wherein: L and M are independently selected from the group consisting of C1-C6 alkyl, phenyl, benzyl, trialkylsilyl, -2,2,2-trichloroethoxy and 2-trimethylsilylethoxy.
申请公布号 HK1148533(A1) 申请公布日期 2013.02.01
申请号 HK20110102611 申请日期 2011.03.15
申请人 BRISTOL-MYERS SQUIBB COMPANY 发明人 YASUTSUGU UEDA;TIMOTHY P. CONNOLLY;JOHN F. KADOW;NICHOLAS A. MEANWELL;TAO WANG;CHUNG-PIN H. CHEN;KAP-SUN YEUNG;ZHONGXING ZHANG;DAVID KENNETH LEAHY;SHAWN K. PACK;NACHIMUTHU SOUNDARARAJAN;PIERRE SIRARD;KATHIA LEVESQUE;DOMINIQUE THORAVAL
分类号 A61K31/437;A61K31/496;A61K31/675;C07D471/04;C07F;C07F9/09;C07F9/572;C07F9/6561 主分类号 A61K31/437
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