发明名称 |
RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA) |
摘要 |
The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of CTNNB1 gene expression and/or activity, and/or modulate a beta-catenin gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against CTNNB1 gene expression. |
申请公布号 |
AU2011285909(A8) |
申请公布日期 |
2013.01.31 |
申请号 |
AU20110285909 |
申请日期 |
2011.08.02 |
申请人 |
MERCK SHARP & DOHME CORP. |
发明人 |
BROWN, DUNCAN;CUNNINGHAM, JAMES J.;GINDY, MARIAN;PICKERING, VICTORIA;STANTON, MATTHEW G.;STIRDIVANT, STEVEN M.;STRAPPS, WALTER |
分类号 |
A61K48/00;C12N15/11 |
主分类号 |
A61K48/00 |
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