发明名称 |
METHOD FOR DETECTING REGULATORY T CELLS USING EXPRESSION OF FOLATE RECEPTOR 4 AS INDICATOR, METHOD FOR TREATING DISEASES USING THE DETECTION METHOD, PHARMACEUTICAL COMPOSITION FOR IMMUNOSTIMULATION, AND METHOD FOR TREATING DISEASES USING THE COMPOSITION |
摘要 |
An object of the present invention is to provide a technique to distinguish between Treg cells and activated T cells in a live state. Another object of the present invention is to provide a pharmaceutical composition for immunostimulation that can reduce the number of Treg cells in vivo and effectively express the immune response of activated T cells. In the method of the present invention, Treg cells are detected from test cells containing (i) regulatory T cells and (ii) at least one type of cell selected from the group consisting of naive T cells and activated T cells, wherein expressions of folate receptor 4 on the surfaces of cells are measured and Treg cells are detected using the expressions as an indicator. The present invention uses anti-folate receptor 4 antibody or folate receptor 4-binding fragment as an active ingredient contained in a pharmaceutical composition for immunostimulation.
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申请公布号 |
US2013028890(A1) |
申请公布日期 |
2013.01.31 |
申请号 |
US201213617027 |
申请日期 |
2012.09.14 |
申请人 |
RIKEN;KYOTO UNIVERSITY;SAKAGUCHI SHIMON;HIROTA KEIJI;YAMAGUCHI TOMOYUKI |
发明人 |
SAKAGUCHI SHIMON;HIROTA KEIJI;YAMAGUCHI TOMOYUKI |
分类号 |
A61K39/395;A61P35/00;A61P37/04 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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