3-PHENYLPYRAZOLO[5,1-b]THIAZOLE COMPOUND

摘要

A compound represented by the following formula (I), or salt thereof exhibits excellent CRF receptor antagonism, and sufficient pharmacological activity, safety and pharmacokinetic properties as a drug.
wherein R 1 represents the formula -A 11 -A 12 ; R 2 represents tetrahydrofurylmethyl, tetrahydropyranylmethyl or tetrahydropyranyl; A 11 represents a single bond, methylene or 1,2-ethylene; A 12 represents C1-6 alkyl, C3-6 cycloalkyl or C3-6 cycloalkyl having methyl; R 3 represents methoxy, cyano, cyclobutyloxymethyl, methoxymethyl or ethoxymethyl; and R 4 represents methoxy or chlorine.