摘要 |
<p>A solvate of Compound (1) is selected from the group consisting of: Compound 1· H20, Compound 1·ethanoHsopropanol, Compound 1·acetone, Compound 1·ethylacetate, Compound 1·isopropylacetate, Compound l·ethylacetate·2-methyl THF, Compound 1·ethanol, Compound 1·n-butylacetate; Compound 1 ·heptane; Compound 1·2-butanone; and Compound l»methylacetate, wherein Compound 1 is represented by the following structural formula (I): and wherein the Compound 1·H20 are in a molar ratio of 1 : 0.5 to 1 :3 (Compound 1: H20). A method of preparing such a solvate of Compound (1) includes stirring a mixture of Compound (1) and a solvent desired for the formation of the solvate of Compound (1).</p> |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED;LUISI, BRIAN;ROEPER, STEFANIE;WILLCOX, DAVID;WANG, HONGREN;MUDUNURI, PRAVEEN;LUONG, HOA, Q. |
发明人 |
LUISI, BRIAN;ROEPER, STEFANIE;WILLCOX, DAVID;WANG, HONGREN;MUDUNURI, PRAVEEN;LUONG, HOA, Q. |