发明名称 |
BIOSYNTHETIC SYSTEM THAT PRODUCES IMMUNOGENIC POLYSACCHARIDES IN PROKARYOTIC CELLS |
摘要 |
The invention is directed to bioconjugate vaccines comprising N-glycosylated proteins. Further, the present invention is directed to a recombinant prokaryotic biosynthetic system comprising nucleic acids encoding an epimerase that synthesizes an oligo- or polysaccharide having N-acetylgalactosamine at the reducing terminus. The invention is further directed to N-glycosylated proteins containing an oligo- or polysaccharide having N-acetylgalactosamine at the reducing terminus and an expression system and methods for producing such N-glycosylated proteins.
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申请公布号 |
US2013028926(A1) |
申请公布日期 |
2013.01.31 |
申请号 |
US201013510859 |
申请日期 |
2010.11.16 |
申请人 |
GLYCOVAXYN AG;WACKER MICHAEL;WAECHTER CHARLES |
发明人 |
WACKER MICHAEL;WAECHTER CHARLES |
分类号 |
A61K39/104;A61P37/04;C07K14/21;C12N15/63;C12P21/00 |
主分类号 |
A61K39/104 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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